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KMID : 0644120130260010059
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Journal of Oriental Gynecology
2013 Volume.26 No. 1 p.59 ~ p.68
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A Study on Acute Oral Toxicity of Pyungwi-san and Fermented Pyungwi-san in ICR Mice
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Jang Doo-Rye
Hwang Youn-Hwan
Jung Ki-Youn
Ha Jeong-Ho
Park Hwa-Yong
Ma Jin-Yeul
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Abstract
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Objectives: This study was conducted to investigate the acute toxicity of Pyungwi-san(Pingwei-san in Chinese) in ICR mice, according to KFDA and OECD guideline.
Methods: In the present study, 15 male and female ICR mice administrated singly by gavage at dose levels of 0 and 2000 mg/kg of Pyungwi-san. During the experimental period, no treatment-related death was observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups.
Results: These results showed that the single oral adminstration of Pyungwi-san (Pingwei-san) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats.
Conclusions: Taken together, the median lethal dose(LD50) of Pyungwi-san (Pingwei-san) was considered to be over 2000 mg/kg body for both sexes.
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KEYWORD
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Pyungwi-san, Acute toxicity, Mice, LD50
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